4mnb

Crystal Structure of a complex between the marine anticancer drug Variolin B and DNA

spinqualitylabelsall models 4mnb, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4mnb is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.4Å Ligands: CO, NA, NCO, VAR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms. Intercalative DNA binding of the marine anticancer drug variolin B.,Canals A, Arribas-Bosacoma R, Albericio F, Alvarez M, Aymami J, Coll M Sci Rep. 2017 Jan 4;7:39680. doi: 10.1038/srep39680. PMID:28051169 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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