4n09

Structure of Trypanosoma brucei brucei adenosine kinase in complex with adenosine and AMPPNP

spinqualitylabelsall models 4n09, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4n09 is a 4 chain structure with sequence from Trypanosoma brucei brucei TREU927. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.6Å Ligands: ADN, ADP, EDO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Trypanosoma brucei is a single-cellular parasite of the genus Kinetoplastida and is the causative agent of African sleeping sickness in humans. Adenosine kinase is a key enzyme in the purine-salvage pathway, phosphorylating adenosine to AMP, and also activates cytotoxic analogues such as cordycepin and Ara-A by their phosphorylation. The structures of T. brucei brucei adenosine kinase (TbAK) in its unliganded open conformation and complexed with adenosine and ADP in the closed conformation are both reported to 2.6 A resolution. The structures give insight into the binding mode of the substrates and the conformational change induced upon substrate binding. This information can be used to guide the improvement of cytotoxic substrate analogues as potential antitrypanosomal drugs. Structures of adenosine kinase from Trypanosoma brucei brucei.,Timm J, Gonzalez-Pacanowska D, Wilson KS Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):34-9. doi:, 10.1107/S2053230X13033621. Epub 2013 Dec 24. PMID:24419613 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Adenosine kinase 3D structures

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