4nbn

Tailoring Small Molecules for an Allosteric Site on Procaspase-6

spinqualitylabelsall models 4nbn, resolution 1.75Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4nbn is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.75Å Ligands: 2J7, PO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CASP6_HUMAN Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. See Also Caspase 3D structures

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