4nw8

Crystal structure of macrocycles containing Abeta17-23 (LV(PHI)(MEA)AED) and Abeta30-36 (AIIGL(ORN)V)

spinqualitylabelsall models 4nw8, resolution 2.02Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4nw8 is a 12 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.02Å Ligands: CL, MEA, NA, ORN, PHI Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed A peptide derived from Abeta17-36 crystallizes to form trimers that further associate to form higher-order oligomers. The trimers consist of three highly twisted beta-hairpins in a triangular arrangement. Two trimers associate face-to-face in the crystal lattice to form a hexamer; four trimers in a tetrahedral arrangement about a central cavity form a dodecamer. These structures provide a working model for the structures of oligomers associated with neurodegeneration in Alzheimer's disease. X-ray Crystallographic Structures of Trimers and Higher-Order Oligomeric Assemblies of a Peptide Derived from Abeta,Spencer RK, Li H, Nowick JS J Am Chem Soc. 2014 Apr 3. PMID:24669800 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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