4nyn
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Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1
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Structural highlights
FunctionRNH_HALSA Nuclease that specifically degrades the RNA of RNA-DNA hybrids; seems to act exonucleolytically on RNA/DNA hybrids. Endonucleolytically removes RNA primers from the Okazaki fragments of lagging strand synthesis on its own. Complements the temperature-sensitive phenotype of an E.coli double rnhA/rnhB (RNase H) disruption mutant.[1] See AlsoReferences
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This page was last modified 14:51, 8 November 2023.