4ok0

Crystal structure of putative nucleotidyltransferase from H. pylori

spinqualitylabelsall models 4ok0, resolution 2.17Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ok0 is a 2 chain structure with sequence from Helicobacter pylori J99. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.17Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9ZKK2_HELPJ Publication Abstract from PubMed The jhp0933 gene in the plasticity region of Helicobacter pylori J99 encodes a hypothetical protein (JHP933), which may play some roles in pathogenesis. Here, we have determined the crystal structure of JHP933 at 2.17 A. It represents the first crystal structure of the DUF1814 protein family. JHP933 consists of two domains: an N-terminal domain of the nucleotidyltransferase (NTase) fold and a C-terminal helix bundle domain. A highly positively-charged surface patch exists adjacent to the putative NTP binding site. Structural similarity of JHP933 to known NTases is very remote, suggesting that it may function as a novel nucleotidyltransferase. (c) Proteins 2014;. (c) 2014 Wiley Periodicals, Inc. Crystal structure of JHP933 from Helicobacter pylori J99 shows two-domain architecture with a DUF1814 family nucleotidyltransferase domain and a helical bundle domain.,Yoon JY, Lee SJ, Kim DJ, Lee BJ, Yang JK, Suh SW Proteins. 2014 Mar 27. doi: 10.1002/prot.24572. PMID:24677396 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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