4r8z

Crystal Structure of PA4781 HD-GYP domain from Pseudomonas aeruginosa at 2.2A resolution showing a bi-metallic Ni ion center

spinqualitylabelsall models 4r8z, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4r8z is a 2 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.2Å Ligands: CL, NI Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CDPD2_PSEAE Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP (PubMed:19170727, PubMed:24066157). Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine (pGpG). In vitro, can use pGpG as an alternative substrate and hydrolyze it into GMP (PubMed:24066157). Acts in regulation of motility, synthesis of virulence determinants and biofilm architecture (PubMed:19170727). May act preferentially as a pGpG binding protein (PubMed:24066157). See Also Phosphodiesterase 3D structures

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