| Structural highlights
4rco is a 2 chain structure with sequence from Staphylococcus aureus subsp. aureus NCTC 8325. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | X-ray diffraction, Resolution 1.9Å |
| Ligands: | CL, FUC, GAL, NDG, PRD_900122, SIA |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
SSL4_STAA8 Secreted protein that plays a role in immune innate response inhibition by interfering with host TLR2-mediated pathway.[1] [2]
References
- ↑ Bardoel BW, Vos R, Bouman T, Aerts PC, Bestebroer J, Huizinga EG, Brondijk TH, van Strijp JA, de Haas CJ. Evasion of Toll-like receptor 2 activation by staphylococcal superantigen-like protein 3. J Mol Med (Berl). 2012 Oct;90(10):1109-20. PMID:22714643 doi:10.1007/s00109-012-0926-8
- ↑ Koymans KJ, Goldmann O, Karlsson CAQ, Sital W, Thänert R, Bisschop A, Vrieling M, Malmström J, van Kessel KPM, de Haas CJC, van Strijp JAG, Medina E. The TLR2 Antagonist Staphylococcal Superantigen-Like Protein 3 Acts as a Virulence Factor to Promote Bacterial Pathogenicity in vivo. J Innate Immun. 2017;9(6):561-573. PMID:28858870 doi:10.1159/000479100
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