4rwr

2.1 Angstrom Crystal Structure of Stage II Sporulation Protein D from Bacillus anthracis

spinqualitylabelsall models 4rwr, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4rwr is a 2 chain structure with sequence from Bacillus anthracis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.1Å Ligands: MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A6L7HNW1_BACAN Publication Abstract from PubMed Bacterial spores are the most resistant form of life known on the Earth and represent a serious problem for i) bioterrorism attack, ii) horizontal transmission of microbial pathogens in the community and iii) persistence in patients and in a nosocomial environment. SpoIID (Stage II Sporulation Protein D) is a Lytic Transglycosylase (LT) essential for sporulation. The LT-superfamily is a potential drug target because they are active in essential bacterial processes involving the peptidoglycan (PGN), which is unique to bacteria. However, the absence of structural information for the sporulation specific LT enzymes has hindered mechanistic understanding of SpoIID. Here, we report the first crystal structures with and without ligands of the SpoIID family from two community relevant spore-forming pathogens, Bacillus anthracis and Clostridium difficile. The structures allow us to visualize the overall architecture, characterize the substrate recognition model, identify critical residues and provide the structural basis for catalysis by this new family of enzymes. Crystal structures of the SpoIID lytic transglycosylases essential for bacterial sporulation.,Nocadello S, Minasov G, Shuvalova LS, Dubrovska I, Sabini E, Anderson WF J Biol Chem. 2016 May 18. pii: jbc.M116.729749. PMID:27226615 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Proteopedia Page Contributors and Editors (what is this?)

OCA