4u36

Crystal structure of a seed lectin from Vatairea macrocarpa complexed with Tn-antigen

spinqualitylabelsall models 4u36, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4u36 is a 1 chain structure with sequence from Vatairea macrocarpa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.4Å Ligands: A2G, CA, CIT, MN, SER, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function LECS_VATMA Lectin that binds galactose. Publication Abstract from PubMed Plant lectins have been studied as histological markers and promising antineoplastic molecules for a long time, and structural characterization of different lectins bound to specific cancer epitopes has been carried out successfully. The crystal structures of Vatairea macrocarpa (VML) seed lectin in complex with GalNAc-alpha-O-Ser (Tn antigen) and GalNAc have been determined at the resolution of 1.4A and 1.7A, respectively. Molecular docking analysis of this new structure and other Tn-binding legume lectins to O-mucin fragments differently decorated with this antigen provides a comparative binding profile among these proteins, stressing that subtle alterations that may not influence monosaccharide binding can, nonetheless, directly impact the ability of these lectins to recognize naturally occurring antigens. In addition to the specific biological effects of VML, the structural and binding similarities between it and other lectins commonly used as histological markers (e.g., VVLB4 and SBA) strongly suggest VML as a candidate tool for cancer research. High-resolution structure of a new Tn antigen-binding lectin from Vatairea macrocarpa and a comparative analysis of Tn-binding legume lectins.,de Sousa BL, da Silva Filho JC, Kumar P, Pereira RI, Lyskowski A, da Rocha BA, Delatorre P, Bezerra GA, Nagano CS, Gruber K, Cavada BS Int J Biochem Cell Biol. 2014 Dec 12. pii: S1357-2725(14)00385-9. doi:, 10.1016/j.biocel.2014.12.002. PMID:25499445 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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