4u5m

Structure of a left-handed DNA G-quadruplex

spinqualitylabelsall models 4u5m, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4u5m is a 1 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.5Å Ligands: K, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements. Structure of a left-handed DNA G-quadruplex.,Chung WJ, Heddi B, Schmitt E, Lim KW, Mechulam Y, Phan AT Proc Natl Acad Sci U S A. 2015 Feb 18. pii: 201418718. PMID:25695967 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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