4uqg

A new bio-isosteric base pair based on reversible bonding

spinqualitylabelsall models 4uqg, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4uqg is a 3 chain structure with sequence from Geobacillus stearothermophilus and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2Å Ligands: FRU, GLC, PRD_900003, SAY, SO4, T0T Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function E1C9K5_GEOSE Publication Abstract from PubMed We report the development of a new heterobase that is held together through reversible bonding. The so-formed cross-link adds strong stabilization to the DNA duplex. Despite this, the cross-link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross-link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications. "Post-It" Type Connected DNA Created with a Reversible Covalent Cross-Link.,Tomas-Gamasa M, Serdjukow S, Su M, Muller M, Carell T Angew Chem Int Ed Engl. 2014 Nov 28. doi: 10.1002/anie.201407854. PMID:25446281 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also DNA polymerase 3D structures

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