4v0h

Human metallo beta lactamase domain containing protein 1 (hMBLAC1)

spinqualitylabelsall models 4v0h, resolution 1.79Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4v0h is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.79Å Ligands: FE, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MBLC1_HUMAN Publication Abstract from PubMed Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3' stem-loop instead of the otherwise universal polyA tail. A metallo beta-lactamase (MBL) fold enzyme, cleavage and polyadenylation specificity factor 73 (CPSF73), is proposed to be the sole endonuclease responsible for 3' end processing of both mRNA classes. We report cellular, genetic, biochemical, substrate selectivity, and crystallographic studies providing evidence that an additional endoribonuclease, MBL domain containing protein 1 (MBLAC1), is selective for 3' processing of RD histone pre-mRNA during the S-phase of the cell cycle. Depletion of MBLAC1 in cells significantly affects cell cycle progression thus identifying MBLAC1 as a new type of S-phase-specific cancer target. Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.,Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ Elife. 2018 Dec 3;7. pii: 39865. doi: 10.7554/eLife.39865. PMID:30507380 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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