4v88

The structure of the eukaryotic ribosome at 3.0 A resolution.

spinqualitylabelsall models 4v88, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4v88 is a 19 chain structure with sequence from Saccharomyces cerevisiae S288C. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Ligands: MG, N, OHX, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RS6A_YEAST Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Publication Abstract from PubMed Ribosomes translate genetic information encoded by messenger RNA into proteins. Many aspects of translation and its regulation are specific to eukaryotes, whose ribosomes are much larger and intricate than their bacterial counterparts. We report the crystal structure of the 80S ribosome from the yeast Saccharomyces cerevisiae--including nearly all ribosomal RNA bases and protein side chains as well as an additional protein, Stm1--at a resolution of 3.0 angstroms. This atomic model reveals the architecture of eukaryote-specific elements and their interaction with the universally conserved core, and describes all eukaryote-specific bridges between the two ribosomal subunits. It forms the structural framework for the design and analysis of experiments that explore the eukaryotic translation apparatus and the evolutionary forces that shaped it. The structure of the eukaryotic ribosome at 3.0 A resolution.,Ben-Shem A, Garreau de Loubresse N, Melnikov S, Jenner L, Yusupova G, Yusupov M Science. 2011 Dec 16;334(6062):1524-9. Epub 2011 Nov 17. PMID:22096102 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ribosomal protein P0 Ribosomal protein P1 Ribosomal protein P2 Ribosomal protein S1 Ribosome 3D structures 3D sructureseceptor for activated protein kinase C 1

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