4v8p

T.thermophila 60S ribosomal subunit in complex with initiation factor 6.

spinqualitylabelsall models 4v8p, resolution 3.52Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4v8p is a 40 chain structure with sequence from Tetrahymena thermophila. This structure supersedes the now removed PDB entries 4a17, 4a18, 4a19, 4a1a, 4a1b, 4a1c, 4a1d and 4a1e. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.52Å Ligands: MG, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RL37_TETTS Binds to the 23S rRNA. Publication Abstract from PubMed Protein synthesis in all organisms is catalyzed by ribosomes. In comparison to their prokaryotic counterparts, eukaryotic ribosomes are considerably larger and are subject to more complex regulation. The large ribosomal subunit (60S) catalyzes peptide bond formation and contains the nascent polypeptide exit tunnel. We present the structure of the 60S ribosomal subunit from Tetrahymena thermophila in complex with eukaryotic initiation factor 6 (eIF6), cocrystallized with the antibiotic cycloheximide (a eukaryotic-specific inhibitor of protein synthesis), at a resolution of 3.5 angstroms. The structure illustrates the complex functional architecture of the eukaryotic 60S subunit, which comprises an intricate network of interactions between eukaryotic-specific ribosomal protein features and RNA expansion segments. It reveals the roles of eukaryotic ribosomal protein elements in the stabilization of the active site and the extent of eukaryotic-specific differences in other functional regions of the subunit. Furthermore, it elucidates the molecular basis of the interaction with eIF6 and provides a structural framework for further studies of ribosome-associated diseases and the role of the 60S subunit in the initiation of protein synthesis. Crystal structure of the eukaryotic 60S ribosomal subunit in complex with initiation factor 6.,Klinge S, Voigts-Hoffmann F, Leibundgut M, Arpagaus S, Ban N Science. 2011 Nov 18;334(6058):941-8. Epub 2011 Nov 3. PMID:22052974 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ribosome 3D structures

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