4wxj | pdb_00004wxj

Drosophila muscle GluRIIB complex with glutamate

spinqualitylabelsall models 4wxj, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4wxj is a 2 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.002Å Ligands: GLU Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9VMP3_DROME Publication Abstract from PubMed The Drosophila larval neuromuscular junction (NMJ), at which glutamate acts as the excitatory neurotransmitter, is a widely used model for genetic analysis of synapse function and development. Despite decades of study, the inability to reconstitute NMJ glutamate receptor function using heterologous expression systems has complicated the analysis of receptor function, such that it is difficult to resolve the molecular basis for compound phenotypes observed in mutant flies. We find that Drosophila Neto functions as an essential component required for the function of NMJ glutamate receptors, permitting analysis of glutamate receptor responses in Xenopus oocytes. In combination with a crystallographic analysis of the GluRIIB ligand binding domain, we use this system to characterize the subunit dependence of assembly, channel block, and ligand selectivity for Drosophila NMJ glutamate receptors. Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors.,Han TH, Dharkar P, Mayer ML, Serpe M Proc Natl Acad Sci U S A. 2015 Apr 27. pii: 201500458. PMID:25918369 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Glutamate receptor 3D structures

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