4zyo

Crystal Structure of Human Integral Membrane Stearoyl-CoA Desaturase with Substrate

Structural highlights

4zyo is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.25Å
Ligands:	LMT, ST9, ZN
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SCD_HUMAN Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity).[UniProtKB:P13516]^[1] ^[2] ^[3]

References

↑ Zhang S, Yang Y, Shi Y. Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. Biochem J. 2005 May 15;388(Pt 1):135-42. PMID:15610069 doi:10.1042/BJ20041554
↑ Wang J, Yu L, Schmidt RE, Su C, Huang X, Gould K, Cao G. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem Biophys Res Commun. 2005 Jul 8;332(3):735-42. PMID:15907797 doi:10.1016/j.bbrc.2005.05.013
↑ Goren MA, Fox BG. Wheat germ cell-free translation, purification, and assembly of a functional human stearoyl-CoA desaturase complex. Protein Expr Purif. 2008 Dec;62(2):171-8. PMID:18765284 doi:10.1016/j.pep.2008.08.002

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OCA

[1] Zhang S, Yang Y, Shi Y. Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells. Biochem J. 2005 May 15;388(Pt 1):135-42. PMID:15610069 doi:10.1042/BJ20041554

[2] Wang J, Yu L, Schmidt RE, Su C, Huang X, Gould K, Cao G. Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem Biophys Res Commun. 2005 Jul 8;332(3):735-42. PMID:15907797 doi:10.1016/j.bbrc.2005.05.013

[3] Goren MA, Fox BG. Wheat germ cell-free translation, purification, and assembly of a functional human stearoyl-CoA desaturase complex. Protein Expr Purif. 2008 Dec;62(2):171-8. PMID:18765284 doi:10.1016/j.pep.2008.08.002

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4zyo

Crystal Structure of Human Integral Membrane Stearoyl-CoA Desaturase with Substrate

Structural highlights

Function

References

Contents

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