5b87

Crystal structure of a Cysteine Desulfurase from Thermococcus onnurineus NA1 in complex with alanine at 2.3 Angstrom resolution

spinqualitylabelsall models 5b87, resolution 2.28Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5b87 is a 2 chain structure with sequence from Thermococcus onnurineus NA1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.28Å Ligands: ALA, CSS, PLP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B6YT87_THEON Publication Abstract from PubMed Thermococcus onnurineus NA1 is an anaerobic archaeon usually found in a deep-sea hydrothermal vent area, which can use elemental sulfur (S(0)) as a terminal electron acceptor for energy. Sulfur, essential to many biomolecules such as sulfur-containing amino acids and cofactors including iron-sulfur cluster, is usually mobilized from cysteine by the pyridoxal 5'-phosphate- (PLP-) dependent enzyme of cysteine desulfurase (CDS). We determined the crystal structures of CDS from Thermococcus onnurineus NA1 (ToCDS), which include native internal aldimine (NAT), gem-diamine (GD) with alanine, internal aldimine structure with existing alanine (IAA), and internal aldimine with persulfide-bound Cys356 (PSF) structures. The catalytic intermediate structures showed the dihedral angle rotation of Schiff-base linkage relative to the PLP pyridine ring. The ToCDS structures were compared with bacterial CDS structures, which will help us to understand the role and catalytic mechanism of ToCDS in the archaeon Thermococcus onnurineus NA1. Catalytic Intermediate Crystal Structures of Cysteine Desulfurase from the Archaeon Thermococcus onnurineus NA1.,Ho TH, Huynh KH, Nguyen DQ, Park H, Jung K, Sur B, Ahn YJ, Cha SS, Kang LW Archaea. 2017 Apr 24;2017:5395293. doi: 10.1155/2017/5395293. eCollection 2017. PMID:28536498 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Cysteine desulfurase 3D structures

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