5chb

Crystal structure of nvPizza2-S16H58 coordinating a CdCl2 nanocrystal

spinqualitylabelsall models 5chb, resolution 1.55Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5chb is a 3 chain structure with sequence from Synthetic construct. This structure supersedes the now removed PDB entry 4zco. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.55Å Ligands: CD, CL, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed We have engineered a metal-binding site into the novel artificial beta-propeller protein Pizza. This new Pizza variant carries two nearly identical domains per polypeptide chain, and forms a trimer with three-fold symmetry. The designed single metal ion binding site lies on the symmetry axis, bonding the trimer together. Two copies of the trimer associate in the presence of cadmium chloride in solution, and very high-resolution X-ray crystallographic analysis reveals a nanocrystal of cadmium chloride, sandwiched between two trimers of the protein. This nanocrystal, containing seven cadmium ions lying in a plane and twelve interspersed chloride ions, is the smallest reported to date. Our results indicate the feasibility of using rationally designed symmetrical proteins to biomineralize nanocrystals with useful properties. Biomineralization of a Cadmium Chloride Nanocrystal by a Designed Symmetrical Protein.,Voet AR, Noguchi H, Addy C, Zhang KY, Tame JR Angew Chem Int Ed Engl. 2015 Jul 1. doi: 10.1002/anie.201503575. PMID:26136355 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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