5cnr

Crystal structure-guided design of self-assembling RNA nano triangles

spinqualitylabelsall models 5cnr, resolution 2.59Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5cnr is a 4 chain structure with sequence from Senecavirus A. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.59Å Ligands: CL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed RNA nanotechnology uses RNA structural motifs to build nanosized architectures that assemble through selective base-pair interactions. Herein, we report the crystal-structure-guided design of highly stable RNA nanotriangles that self-assemble cooperatively from short oligonucleotides. The crystal structure of an 81 nucleotide nanotriangle determined at 2.6 A resolution reveals the so-far smallest circularly closed nanoobject made entirely of double-stranded RNA. The assembly of the nanotriangle architecture involved RNA corner motifs that were derived from ligand-responsive RNA switches, which offer the opportunity to control self-assembly and dissociation. Crystal-Structure-Guided Design of Self-Assembling RNA Nanotriangles.,Boerneke MA, Dibrov SM, Hermann T Angew Chem Int Ed Engl. 2016 Feb 23. doi: 10.1002/anie.201600233. PMID:26914842 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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