5d9e

Crystal Structure of the Proline-rich Lasso Peptide Caulosegnin II

spinqualitylabelsall models 5d9e, resolution 0.86Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5d9e is a 1 chain structure with sequence from Caulobacter segnis ATCC 21756. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 0.859Å Ligands: CL, SME Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function D5VKJ8_CAUST Publication Abstract from PubMed Lasso peptides are fascinating natural products with a unique structural fold that can exhibit tremendous thermal stability. Here, we investigate factors responsible for the thermal stability of caulosegnin II. By employing X-ray crystallography, mutational analysis and molecular dynamics simulations, the ring residue proline 8 was proven to be crucial for thermal stability. The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.,Hegemann JD, Fage CD, Zhu S, Harms K, Di Leva FS, Novellino E, Marinelli L, Marahiel MA Mol Biosyst. 2016 Feb 11. PMID:26863937 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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