5dae

Kazal type inhibitor from salivary glands of Aedes aegypti mosquito

spinqualitylabelsall models 5dae, resolution 1.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5dae is a 2 chain structure with sequence from Aedes aegypti. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.4Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q1HRB8_AEDAE Publication Abstract from PubMed Blood-feeding exoparasites are rich sources of protease inhibitors, and the mosquito Aedes aegypti, which is a vector of Dengue virus, Yellow fever virus, Chikungunya virus and Zika virus, is no exception. AaTI is a single-domain, noncanonical Kazal-type serine proteinase inhibitor from A. aegypti that recognizes both digestive trypsin-like serine proteinases and the central protease in blood clotting, thrombin, albeit with an affinity that is three orders of magnitude lower. Here, the 1.4 A resolution crystal structure of AaTI is reported from extremely tightly packed crystals ( approximately 22% solvent content), revealing the structural determinants for the observed inhibitory profile of this molecule. High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti.,Torquato RJS, Lu S, Martins NH, Tanaka AS, Pereira PJB Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):469-475. doi:, 10.1107/S2053230X17010007. Epub 2017 Jul 26. PMID:28777090 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Trypsin inhibitor 3D structures

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