5dom

Crystal structure, maturation and flocculating properties of a 2S albumin from Moringa oleifera seeds

spinqualitylabelsall models 5dom, resolution 1.69Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5dom is a 1 chain structure with sequence from Moringa oleifera. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.69Å Ligands: ACT, EDO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function W5S2D2_MOROL Publication Abstract from PubMed 2S albumins, the seed storage proteins, are the primary sources of carbon and nitrogen and are involved in plant defense. The mature form of Moringa oleifera (M. oleifera), a chitin binding protein isoform 3-1 (mMo-CBP3-1) a thermostable antifungal, antibacterial, flocculating 2S albumin is widely used for the treatment of water and is potentially interesting for the development of both antifungal drugs and transgenic crops. The crystal structure of mMo-CBP3-1 determined at 1.7 A resolution demonstrated that it is comprised of two proteolytically processed alpha-helical chains, stabilized by four disulfide bridges that is stable, resistant to pH changes and has a melting temperature (TM) of approximately 98 degrees C. The surface arginines and the polyglutamine motif are the key structural factors for the observed flocculating, antibacterial and antifungal activities. This represents the first crystal structure of a 2S albumin and the model of the pro-protein indicates the structural changes that occur upon formation of mMo-CBP3-1 and determines the structural motif and charge distribution patterns for the diverse observed activities. Crystal structure of mature 2S albumin from Moringa oleifera seeds.,Ullah A, Mariutti RB, Masood R, Caruso IP, Gravatim Costa GH, Millena de Freita C, Santos CR, Zanphorlin LM, Rossini Mutton MJ, Murakami MT, Arni RK Biochem Biophys Res Commun. 2015 Dec 4;468(1-2):365-71. doi:, 10.1016/j.bbrc.2015.10.087. Epub 2015 Oct 23. PMID:26505799 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Albumin 3D structures

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