5doq

The structure of bd oxidase from Geobacillus thermodenitrificans

spinqualitylabelsall models 5doq, resolution 3.05Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5doq is a 3 chain structure with sequence from Geobacillus sp. PA-3 and Geobacillus thermodenitrificans NG80-2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.05Å Ligands: HDD, HEB Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A4IKP6_GEOTN Publication Abstract from PubMed The cytochrome bd oxidases are terminal oxidases that are present in bacteria and archaea. They reduce molecular oxygen (dioxygen) to water, avoiding the production of reactive oxygen species. In addition to their contribution to the proton motive force, they mediate viability under oxygen-related stress conditions and confer tolerance to nitric oxide, thus contributing to the virulence of pathogenic bacteria. Here we present the atomic structure of the bd oxidase from Geobacillus thermodenitrificans, revealing a pseudosymmetrical subunit fold. The arrangement and order of the heme cofactors support the conclusions from spectroscopic measurements that the cleavage of the dioxygen bond may be mechanistically similar to that in the heme-copper-containing oxidases, even though the structures are completely different. Structure of a bd oxidase indicates similar mechanisms for membrane-integrated oxygen reductases.,Safarian S, Rajendran C, Muller H, Preu J, Langer JD, Ovchinnikov S, Hirose T, Kusumoto T, Sakamoto J, Michel H Science. 2016 Apr 29;352(6285):583-6. doi: 10.1126/science.aaf2477. PMID:27126043 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Cytochrome bd oxidase

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