5e9o

Spirochaeta thermophila X module - CBM64 - mutant G504A

spinqualitylabelsall models 5e9o, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5e9o is a 4 chain structure with sequence from Spirochaeta thermophila. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.1Å Ligands: I3C Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function E0RQU0_SPITD Publication Abstract from PubMed Spirochaeta thermophila secretes seven glycoside hydrolases for plant biomass degradation that carry a carbohydrate-binding module 64 (CBM64) appended at the C-terminus. CBM64 adsorbs to various beta1-4-linked pyranose substrates showing high affinity for cellulose. We present the first crystal structure of a CBM64 at 1.2 A resolution, which reveals a jelly-roll-like fold corresponding to a surface-binding type A CBM. Modeling of its interaction with cellulose indicates that CBM64 achieves association with the hydrophobic face of beta-linked pyranose chains via a unique coplanar arrangement of four exposed tryptophan side chains. This article is protected by copyright. All rights reserved. Structural basis for cellulose binding by the type A carbohydrate-binding module 64 of Spirochaeta thermophila.,Schiefner A, Angelov A, Liebl W, Skerra A Proteins. 2016 Feb 12. doi: 10.1002/prot.25010. PMID:26868291 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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