5edw
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Ternary structure of Dpo4 bound to G in the template base paired with incoming dTTP
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Structural highlights
FunctionDPO4_SACS2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis. See AlsoContents | ||||||||||||||||||||
This page was last modified 06:22, 5 July 2023.