5fcz

Streptomyces plicatus N-acetyl-beta-hexosaminidase in complex with Thio-NAglucal (TNX)

spinqualitylabelsall models 5fcz, resolution 2.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5fcz is a 1 chain structure with sequence from Streptomyces plicatus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.45Å Ligands: CL, GOL, SO4, TNX Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function O85361_STRPL Publication Abstract from PubMed Mono-, di- and trisaccharide derivatives of 1,2-unsaturated N-acetyl-d-glucal have been synthesized and shown to function as tight-binding inhibitors/slow substrates of representative hexosaminidases. Turnover is slow and not observed in the thioamide analogue, allowing determination of the 3-dimensional structure of the complex. Inhibition is insensitive to pH and to mutation of key catalytic residues, consistent with the uncharged character of the inhibitor. These properties could render this inhibitor class less prone to development of resistance. N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases.,Santana AG, Vadlamani G, Mark BL, Withers SG Chem Commun (Camb). 2016 Jun 28;52(51):7943-6. doi: 10.1039/c6cc02520j. Epub 2016, Jun 2. PMID:27253678 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Beta-N-acetylhexosaminidase 3D structures

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