5hix

Cocrystal structure of an anti-parallel DNA G-quadruplex and a tetra-Quinoline Foldamer

spinqualitylabelsall models 5hix, resolution 2.48Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5hix is a 2 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.48Å Ligands: 61Q, K Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Quinoline-based oligoamide foldamers have been identified as a potent class of ligands for G-quadruplex DNA. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report a co-crystal structure of the antiparallel hairpin dimeric DNA G-quadruplex (G4 T4 G4 )2 with tetramer 1-a helically folded oligo-quinolinecarboxamide bearing cationic side chains-that is consistent with this hypothesis. Multivalent foldamer-DNA interactions that modify the packing of (G4 T4 G4 )2 in the solid state are observed. Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State.,Mandal PK, Baptiste B, Langlois d'Estaintot B, Kauffmann B, Huc I Chembiochem. 2016 Oct 17;17(20):1911-1914. doi: 10.1002/cbic.201600281. Epub 2016, Aug 19. PMID:27472456 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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