| Structural highlights
Function
HTMR_MYCTU Represses expression of the HQNO methyltransferase htm gene (Rv0560c) by binding to its promoter region (PubMed:26303802, PubMed:27432954, PubMed:28743871). Also represses the expression of at least five other genes, including the methyltransferase Rv0558 (PubMed:26303802). Binds salicylate (SA), para-aminosalicylic acid (PAS) and gemfibrozil (PubMed:28743871).[1] [2] [3]
References
- ↑ Winglee K, Lun S, Pieroni M, Kozikowski A, Bishai W. Mutation of Rv2887, a marR-like gene, confers Mycobacterium tuberculosis resistance to an imidazopyridine-based agent. Antimicrob Agents Chemother. 2015 Nov;59(11):6873-81. PMID:26303802 doi:10.1128/AAC.01341-15
- ↑ Warrier T, Kapilashrami K, Argyrou A, Ioerger TR, Little D, Murphy KC, Nandakumar M, Park S, Gold B, Mi J, Zhang T, Meiler E, Rees M, Somersan-Karakaya S, Porras-De Francisco E, Martinez-Hoyos M, Burns-Huang K, Roberts J, Ling Y, Rhee KY, Mendoza-Losana A, Luo M, Nathan CF. N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4523-30. doi:, 10.1073/pnas.1606590113. Epub 2016 Jul 18. PMID:27432954 doi:https://dx.doi.org/10.1073/pnas.1606590113
- ↑ Gao YR, Li DF, Fleming J, Zhou YF, Liu Y, Deng JY, Zhou L, Zhou J, Zhu GF, Zhang XE, Wang DC, Bi LJ. Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis. Sci Rep. 2017 Jul 25;7(1):6471. doi: 10.1038/s41598-017-01705-4. PMID:28743871 doi:https://dx.doi.org/10.1038/s41598-017-01705-4
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