5i2s

PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN

spinqualitylabelsall models 5i2s, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5i2s is a 1 chain structure with sequence from Vesicular stomatitis Indiana virus strain Mudd-Summers. This structure supersedes the now removed PDB entry 2j6j. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3Å Ligands: NAG, YB Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function VGLG_VSIVM Publication Abstract from PubMed Glycoprotein G of the vesicular stomatitis virus triggers membrane fusion via a low pH-induced structural rearrangement. Despite the equilibrium between the pre- and postfusion states, the structure of the prefusion form, determined to 3.0 angstrom resolution, shows that the fusogenic transition entails an extensive structural reorganization of G. Comparison with the structure of the postfusion form suggests a pathway for the conformational change. In the prefusion form, G has the shape of a tripod with the fusion loops exposed, which point toward the viral membrane, and with the antigenic sites located at the distal end of the molecule. A large number of G glycoproteins, perhaps organized as in the crystals, act cooperatively to induce membrane merging. Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G.,Roche S, Rey FA, Gaudin Y, Bressanelli S Science. 2007 Feb 9;315(5813):843-8. PMID:17289996 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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