5j6x

Crystal structure of the apo-Zalpha of Zebrafish PKZ

spinqualitylabelsall models 5j6x, resolution 2.49Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5j6x is a 2 chain structure with sequence from Danio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.493Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q5NE12_DANRE Publication Abstract from PubMed The Z-DNA-binding domain of PKZ from zebrafish (Danio rerio; drZalphaPKZ ) contains the largest beta-wing among known Z-DNA-binding domains. To elucidate the functional implication of the beta-wing, we solved the crystal structure of apo-drZalphaPKZ . Structural comparison with its Z-DNA-bound form revealed a large conformational change within the beta-wing during Z-DNA binding. Biochemical studies of protein mutants revealed that two basic residues in the beta-wing are responsible for Z-DNA recognition as well as fast B-Z transition. Therefore, the extra basic residues in the beta-wing of drZalphaPKZ are necessary for the fast B-Z transition activity. Structural and functional studies of a large winged Z-DNA-binding domain of Danio rerio protein kinase PKZ.,Subramani VK, Kim D, Yun K, Kim KK FEBS Lett. 2016 Jul;590(14):2275-85. doi: 10.1002/1873-3468.12238. Epub 2016 Jun , 23. PMID:27265117 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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