5jjo

The crystal structure of immunity protein PA5088 from Pseudomonas aeruginosa

spinqualitylabelsall models 5jjo, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5jjo is a 1 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.002Å Ligands: AU Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9HU95_PSEAE Publication Abstract from PubMed The Pseudomonas aeruginosa PldB protein is a transkingdom effector secreted by the Type VI Secretion System (T6SS). PA5088, PA5087, and PA5086 are three immunity proteins that can suppress the virulence of PldB. We report the crystal structures of PA5088 and PA5087 at 2.0 and 2.1 A resolution, respectively. PA5088 and PA5087 both consist of several Sel1-like Repeats (SLRs) and form super-ring folds. Our structural analysis of these proteins revealed key differences among PA5088, PA5087, and their homologs. Our docking experiments have shed light on the putative interaction mechanism of their function as phospholipase D inhibitors. Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins.,Yang XY, Li ZQ, She Z, Geng Z, Xu JH, Gao ZQ, Dong YH FEBS Lett. 2016 Aug;590(16):2787-96. doi: 10.1002/1873-3468.12291. Epub 2016 Jul , 28. PMID:27397502 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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