5kf4

Crystal structure of FN3 domain (Residues P368-P466) of Human collagen XX

spinqualitylabelsall models 5kf4, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5kf4 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.5Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function COKA1_HUMAN Probable collagen protein. Publication Abstract from PubMed Collagen alpha1 type XX, which contains fibronectin type III (FN3) repeats involving six FN3 domains (referred to as the FN#1-FN#6 domains), is an unusual member of the fibril-associated collagens with interrupted triple helices (FACIT) subfamily of collagens. The results of standard protein BLAST suggest that the FN3 repeats might contribute to collagen alpha1 type XX acting as a cytokine receptor. To date, solution NMR structures of the FN#3, FN#4 and FN#6 domains have been determined. To obtain further structural evidence to understand the relationship between the structure and function of the FN3 repeats from collagen alpha1 type XX, the crystal structure of the FN#2 domain from human collagen alpha1 type XX (residues Pro386-Pro466; referred to as FN2-HCXX) was solved at 2.5 A resolution. The crystal structure of FN2-HCXX shows an immunoglobulin-like fold containing a beta-sandwich structure, which is formed by a three-stranded beta-sheet (beta1, beta2 and beta5) packed onto a four-stranded beta-sheet (beta3, beta4, beta6 and beta7). Two consensus domains, tencon and fibcon, are structural analogues of FN2-HCXX. Fn8, an FN3 domain from human oncofoetal fibronectin, is the closest structural analogue of FN2-HCXX derived from a naturally occurring sequence. Based solely on the structural similarity of FN2-HCXX to other FN3 domains, the detailed functions of FN2-HCXX and the FN3 repeats in collagen alpha1 type XX cannot be identified. Crystal structure of the second fibronectin type III (FN3) domain from human collagen alpha1 type XX.,Zhao J, Ren J, Wang N, Cheng Z, Yang R, Lin G, Guo Y, Cai D, Xie Y, Zhao X Acta Crystallogr F Struct Biol Commun. 2017 Dec 1;73(Pt 12):695-700. doi:, 10.1107/S2053230X1701648X. Epub 2017 Nov 21. PMID:29199991 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Collagen 3D structures

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