5kji

Crystal structure of an active polycomb repressive complex 2 in the basal state

spinqualitylabelsall models 5kji, resolution 2.71Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5kji is a 2 chain structure with sequence from Chaetomium thermophilum var. thermophilum DSM 1495. This structure supersedes the now removed PDB entry 5ch2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.71Å Ligands: SAH, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function G0S8H7_CHATD Publication Abstract from PubMed Zhang et al suggested that in the crystal structure of a polycomb repressive complex 2 from Chaetomium thermophilum (ctPRC2), a flexible linker region, but not the H3K27M cancer mutant peptide, better fits the electron density. Based on our new data, we agree with this alternative interpretation and provide the crystal structure of ctPRC2 bound to a bona fide H3K27M sequence. Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".,Jiao L, Liu X Science. 2016 Dec 23;354(6319):1543. doi: 10.1126/science.aaj2335. PMID:28008038 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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