5li0

70S ribosome from Staphylococcus aureus

Loading... Status: waiting for Mol* initialization Structural highlights 5li0 is a 10 chain structure with sequence from Staphylococcus aureus subsp. aureus NCTC 8325. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.8Å Ligands: MG, O, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RS2_STAA8 Publication Abstract from PubMed Comparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact translation specificity and its regulation. Although the importance of such features may be less obvious within more closely related organisms, their existence could account for vital yet species-specific mechanisms of translation regulation that would involve stalling, cell survival and antibiotic resistance. Here, we present the first full 70S ribosome structure from Staphylococcus aureus, a Gram-positive pathogenic bacterium, solved by cryo-electron microscopy. Comparative analysis with other known bacterial ribosomes pinpoints several unique features specific to S. aureus around a conserved core, at both the protein and the RNA levels. Our work provides the structural basis for the many studies aiming at understanding translation regulation in S. aureus and for designing drugs against this often multi-resistant pathogen. Structure of the 70S ribosome from human pathogen Staphylococcus aureus.,Khusainov I, Vicens Q, Bochler A, Grosse F, Myasnikov A, Menetret JF, Chicher J, Marzi S, Romby P, Yusupova G, Yusupov M, Hashem Y Nucleic Acids Res. 2016 Dec 1;44(21):10491-10504. Epub 2016 Oct 18. PMID:27906650 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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