5lvz

Crystal structure of yeast 14-3-3 protein from Lachancea thermotolerans

spinqualitylabelsall models 5lvz, resolution 1.95Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5lvz is a 1 chain structure with sequence from Lachancea thermotolerans CBS 6340. This structure supersedes the now removed PDB entry 5lho. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.95Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function C5DN49_LACTC Publication Abstract from PubMed 14-3-3 proteins bind phosphorylated binding partners to regulate several of their properties, including enzymatic activity, stability and subcellular localization. Here, two crystal structures are presented: the crystal structures of the 14-3-3 protein (also known as Bmh1) from the yeast Lachancea thermotolerans in the unliganded form and bound to a phosphopeptide derived from human PI4KB (phosphatidylinositol 4-kinase B). The structures demonstrate the high evolutionary conservation of ligand recognition by 14-3-3 proteins. The structural analysis suggests that ligand recognition by 14-3-3 proteins evolved very early in the evolution of eukaryotes and remained conserved, underlying the importance of 14-3-3 proteins in physiology. Crystal structures of a yeast 14-3-3 protein from Lachancea thermotolerans in the unliganded form and bound to a human lipid kinase PI4KB-derived peptide reveal high evolutionary conservation.,Eisenreichova A, Klima M, Boura E Acta Crystallogr F Struct Biol Commun. 2016 Nov 1;72(Pt 11):799-803. Epub 2016, Oct 24. PMID:27827352 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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