5m1z

STRUCTURE OF THE ALPHA-L-ARABINOFURANOSIDASE ARB93A FROM FUSARIUM GRAMINEARUM IN COMPLEX WITH AN hydroximolactone INHIBITOR

spinqualitylabelsall models 5m1z, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5m1z is a 1 chain structure with sequence from Fusarium graminearum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2Å Ligands: 6LW, AHR, EDO, GOL, MN, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B8ZY56_GIBZA Publication Abstract from PubMed The synthesis of potent inhibitors of GH93 arabinanases as well as a synthesis of a chromogenic substrate to measure GH93 arabinanase activity is described. An insight into the reasons behind the potency of the inhibitors was gained through X-ray crystallographic analysis using the arabinanase Arb93A from Fusarium graminearum. These compounds lay a foundation for future inhibitor development as well as for the use of the chromogenic substrate in biochemical studies of GH93 arabinanases. Exploiting sp2-hybridization in the development of potent 1,5-a-L-arabinanase inhibitors.,Coyle T, Debowski A, Varrot A, Stubbs KA Chembiochem. 2017 Mar 7. doi: 10.1002/cbic.201700073. PMID:28266777 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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