5n04

X-ray crystal structure of an LPMO

spinqualitylabelsall models 5n04, resolution 1.76Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5n04 is a 1 chain structure with sequence from Panus similis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.76Å Ligands: CL, CU, HIC, NA, NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0S2GKZ1_9APHY Publication Abstract from PubMed Lytic polysaccharide monooxygenases (LPMOs) have been found to be key components in microbial (bacterial and fungal) degradation of biomass. They are copper metalloenzymes that degrade polysaccharides oxidatively and act in synergy with glycoside hydrolases. Recently crystallographic studies carried out at pH 5.5 of the LPMO from Lentinus similis belonging to the fungal LPMO family AA9 have provided the first atomic resolution view of substrate-LPMO interactions. The LsAA9A structure presented here determined at pH 3.5 shows significant disorder of the active site in the absence of substrate ligand. Furthermore some differences are also observed in regards to substrate (cellohexaose) binding, although the major interaction with the N-terminal histidine remains unchanged. Unliganded and substrate bound structures of the cellooligosaccharide active lytic polysaccharide monooxygenase LsAA9A at low pH.,Frandsen KEH, Poulsen JN, Tandrup T, Lo Leggio L Carbohydr Res. 2017 Aug 7;448:187-190. doi: 10.1016/j.carres.2017.03.010. Epub, 2017 Mar 24. PMID:28364950 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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