5nip

An i-motif containing the neutral cytidine protonated analogue pseudoisocytidine

spinqualitylabelsall models 5nip Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5nip is a 2 chain structure with sequence from Synthetic construct. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Ligands: 8YN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure. The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures.,Mir B, Soles X, Gonzalez C, Escaja N Sci Rep. 2017 Jun 5;7(1):2772. doi: 10.1038/s41598-017-02723-y. PMID:28584239 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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