5nlg

RRP5 C-terminal domain

spinqualitylabelsall models 5nlg, resolution 2.35Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5nlg is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.35Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RRP5_YEAST Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA. Publication Abstract from PubMed Rrp5 is an essential factor during the ribosome biogenesis process. The protein contains a series of 12 S1 RNA-binding domains followed by a TetratricoPeptide Repeat (TPR) domain. In the past, several studies aiming at defining the function of the TPR domain have used nonequivalent Rrp5 constructs, as these protein fragments include not only the TPR module, but also three or four S1 domains. We solved the structure of the Rrp5 TPR module and demonstrated in vitro that the TPR region alone does not bind RNA, while the three S1 domains preceding the TPR module can associate with homopolymeric RNA. Finally, we tested the association of our Rrp5 constructs with several proposed interactors, in support of cryo-EM-based models. Coordinates: Atomic coordinates and structure factors have been deposited to the Protein Data Bank under the accession number 5NLG. Structural and interaction analysis of the Rrp5 C-terminal region.,Perebaskine N, Thore S, Fribourg S FEBS Open Bio. 2018 Aug 30;8(10):1605-1614. doi: 10.1002/2211-5463.12495., eCollection 2018 Oct. PMID:30338212 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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