5o0z

Structure of laspartomycin C in complex with geranyl-phosphate

spinqualitylabelsall models 5o0z, resolution 1.28Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5o0z is a 2 chain structure with sequence from Streptomyces viridochromogenes. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.28Å Ligands: 2TL, 9GB, 9GE, ACY, CA, CL, CPI, DNP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The calcium-dependent antibiotics (CDAs) are an important emerging class of antibiotics. We here report the crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl-phosphate at a resolution of 1.28 A. This represents the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C55-P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target. High-resolution crystal structure reveals molecular details of target recognition by the calcium-dependent lipopeptide antibiotic laspartomycin C.,Kleijn LHJ, Vlieg HC, Wood TM, Sastre Torano J, Janssen BJC, Martin NI Angew Chem Int Ed Engl. 2017 Nov 6. doi: 10.1002/anie.201709240. PMID:29108098 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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