5o33

A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1

spinqualitylabelsall models 5o33, resolution 1.64Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5o33 is a 2 chain structure with sequence from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.64Å Ligands: EDO, GDP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function KALRN_RAT Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation. See Also Rac 3D structures

Proteopedia Page Contributors and Editors (what is this?)

OCA