5tum

Crystal structure of tetracycline destructase Tet(56)

spinqualitylabelsall models 5tum, resolution 3.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5tum is a 2 chain structure with sequence from Legionella longbeachae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.299Å Ligands: FAD Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TET56_LEGLN An FAD-requiring monooxygenase active on tetracycline antibiotic and some of its derivatives, which leads to their inactivation (PubMed:26097034). Expression in E.coli confers high resistance to tetracycline and oxytetracycline, does not confer resistance to minocycline or tigecycline. The reaction requires NADPH (PubMed:26097034). Expression in L.pneumophila confers resistance to tetracycline (PubMed:28481346). Degrades and confers resistance to tetracycline and chlortetracycline (PubMed:26097034, PubMed:28481346).

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