5u9s

Ocellatin-F1, solution structure in TFE by NMR spectroscopy

spinqualitylabelsall models 5u9s Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5u9s is a 1 chain structure with sequence from Leptodactylus labyrinthicus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 10 models Ligands: NH2 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function OCEF1_LEPLB Antibacterial peptide that inhibits reference strains of both Gram-negative bacteria (E.coli, P.aeruginosa, E.cloacae, K.pneumoniae, and A.actinomycetemcomitans) and Gram-positive bacteria (S.aureus) with relatively low potencies (MIC=25-400 uM) (By similarity) (PubMed:28115922). Shows antifungal activity against C.lusitaniae (MIC=50.25 uM), but no activity against C.albicans (PubMed:28115922). In the presence of an alkaloid (bufotenine), inhibits cellular infection by the rabies virus (PubMed:26635873). The peptide shows very low hemolytic activity against rabbit erythrocytes (By similarity) (PubMed:28115922). The low amphipathicity of alpha-helices demonstrated by wheel projection as well as the low cationicity may explain the low antibacterial and hemolytic potencies (By similarity).[UniProtKB:P0DQJ8]

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