5uy8

Crystal structure of AICARFT bound to an antifolate

spinqualitylabelsall models 5uy8, resolution 2.39Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5uy8 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.39Å Ligands: 8UM, AMZ, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease PUR9_HUMAN Defects in ATIC are the cause of AICAR transformylase/IMP cyclohydrolase deficiency (AICAR) [MIM:608688. A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA-ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness. Function PUR9_HUMAN Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. See Also Bifunctional purine biosynthesis protein PURH

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