5vkc

Crystal structure of MCL-1 in complex with a BIM competitive inhibitor

spinqualitylabelsall models 5vkc, resolution 2.31Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5vkc is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.31Å Ligands: 9EA, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MCL1_HUMAN Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. See Also B-cell lymphoma proteins 3D structures

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