5wd8

Crystal structure of Legionella pneumophila effector lpg2328

spinqualitylabelsall models 5wd8, resolution 1.94Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5wd8 is a 2 chain structure with sequence from Legionella pneumophila subsp. pneumophila ATCC 43290. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.944Å Ligands: MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Legionella pneumophila is a pathogen causing severe pneumonia in humans called Legionnaires' disease. Lem22 is a previously uncharacterized effector protein conserved in multiple Legionella strains. Here, we report the crystal structure of Lem22 from the Philadelphia strain, also known as lpg2328, at 1.40 A resolution. The structure shows an up-and-down three-helical bundle with a significant structural similarity to a number of protein-binding domains involved in apoptosis and membrane trafficking. Sequence conservation identifies a putative functional site on the interface of helices 2 and 3. The structure is an important step toward a functional characterization of Lem22. Crystal structure of the Legionella effector Lem22.,Kozlov G, Wong K, Gehring K Proteins. 2017 Nov 21. doi: 10.1002/prot.25427. PMID:29159828 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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