5weg

Crystal Structure of UDP-glucose pyrophosphorylase from Sugarcane

spinqualitylabelsall models 5weg, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5weg is a 2 chain structure with sequence from Saccharum hybrid cultivar SP80-3280. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2Å Ligands: EDO, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A075E2Q1_9POAL Publication Abstract from PubMed UDP-glucose pyrophosphorylase (UGPase) is found in all organisms and catalyses the formation of UDP-glucose. In sugarcane, UDP-glucose is a branch-point in the carbon channelling into other carbohydrates, such as sucrose and cellulose, which are the major factors for sugarcane productivity. In most plants, UGPase has been described to be enzymatically active in the monomeric form, while in human and yeast, homo-octamers represent the active form of the protein. Here, we present the crystal structure of UGPase from sugarcane (ScUGPase-1) at resolution of 2.0 A. The crystals of ScUGPase-1 reveal the presence of two molecules in the asymmetric unit and the multi-angle light scattering analysis shows that ScUGPase-1 forms a mixture of species ranging from monomers to larger oligomers in solution, suggesting similarities with the orthologs from yeast and human. Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane.,Cotrim CA, Soares JSM, Kobe B, Menossi M PLoS One. 2018 Mar 1;13(3):e0193667. doi: 10.1371/journal.pone.0193667., eCollection 2018. PMID:29494650 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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