5xa6

Ion channel modulation by scorpion haemolymph and its defensin ingredients uncovers origin of neurotoxins in telson formed in Paleozoic scorpion

spinqualitylabelsall models 5xa6 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5xa6 is a 1 chain structure with sequence from Buthus sp. IY-2001. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 20 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function DEF3_MESMA Antibacterial peptide active against Gram-positive bacteria (including S.aureus ATCC25923 (MIC=2.5 uM), M.luteus AB93113 (MIC=2.5 uM), and the antibiotic-resistant S.epidermidis PRSE P1389 (MIC=1.25 uM)), but not against Gram-negative bacteria (including E.coli and P.aeruginosa) (PubMed:31954123). Also blocks the currents of Kv1.1/KCNA1 (57% inhibition), Kv1.2/KCNA2 (27.5% inhibition), Kv1.3/KCNA3 (IC(50)=23.4 nM, 84.3% inhibition), KCa3.1/KCNN4/IK (15% inhibition), KCa2.3/KCNN3/SK3 (87.5% inhibition) and Kv11.1/KCNH2/ERG1 (30.4% inhibition) channels (tested at 1 uM) (PubMed:31954123). It inhibits potassium channel current by interacting with the pore region (PubMed:31954123).

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