5xbj

The structure of the flagellar hook junction protein HAP1 (FlgK) from Campylobacter jejuni

spinqualitylabelsall models 5xbj, resolution 2.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5xbj is a 1 chain structure with sequence from Campylobacter jejuni. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.448Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q0P8E9_CAMJE Publication Abstract from PubMed Evolution of a nano-machine consisting of multiple parts, each with a specific function, is a complex process. A change in one part should eventually result in changes in other parts, if the overall function is to be conserved. In bacterial flagella, the filament and the hook have distinct functions and their respective proteins, FliC and FlgE, have different three-dimensional structures. The filament functions as a helical propeller and the hook as a flexible universal joint. Two proteins, FlgK and FlgL, assure a smooth connectivity between the hook and the filament. Here we show that, in Campylobacter, the 3D structure of FlgK differs from that of its orthologs in Salmonella and Burkholderia, whose structures have previously been solved. Docking the model of the FlgK junction onto the structure of the Campylobacter hook provides some clues about its divergence. These data suggest how evolutionary pressure to adapt to structural constraints, due to the structure of Campylobacter hook, causes divergence of one element of a supra-molecular complex in order to maintain the function of the entire flagellar assembly. Structure of FlgK reveals the divergence of the bacterial Hook-Filament Junction of Campylobacter.,Bulieris PV, Shaikh NH, Freddolino PL, Samatey FA Sci Rep. 2017 Nov 16;7(1):15743. doi: 10.1038/s41598-017-15837-0. PMID:29147015 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Flagellar protein 3D structures

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